A Skeptical Biochemist (Fruton, Joseph S.)

A skeptical biochemist

Social history, especially of bioethics, is bound to be problematic unless it is predicated upon a clear analysis of the substantive ethical issues. At issue in the 1960s was whether research standards should be subjective guidelines, enforced by the researcher's conscience, externally enforced objective rules, or intersubjective standards enforced by review committees (IRBs). In a series of pa...

How I became a biochemist.

It was a sunny September day in a Madrid that had started to grow after years of stagnation, when I entered a modern red brick building at the corner of Velázquez and Joaquín Costa streets. I had an appointment with someone unknown to me, but whom I had been told was an important enzymologist. I was far from imagining that the encounter with that person would determine my future scientific life...

The Activation of Papain Trypsinase as a Function of the Nature of the Activator by George W. Irving, Jr., Joseph S. Fruton, and Max Bergmann

Papain contains a cysteine-activatable proteinase that hydrolyzes benzoyll-arginlneamide (1). This enzyme has been shown to have a specificity similar to that of crystalline pancreatic trypsin (2) and therefore has been designated papain trypsinase (3). Previous experiments have shown that papain trypsinase exists in two inactive forms which can be designated papain-a-trypsinase and papain-13-t...

s From MO Joseph Hellerstein ne Relationships

Quantitative predictions are typically obtained by characterizing a system in terms of algebraic relationships and then using these relationships to compute quantitative predictions from numerical data. For real-life systems, such as mainframe operating systems, an algebraic characterization is often diicult, if not intractable. This paper proposes a statistical approach to obtaining quantitati...

Joseph S. Redding's contributions to cardiac resuscitation.